We introduce a notion of a pentagonal equation for an adjointable operator on a Hilbert $C^*$-module in full generality. We call a unitary operator on a Hilbert $C^*$-module a multiplicative unitary operator (MUO) when it satisfies the pentagonal equation. We give a sufficient condition for the existence of an MUO associated with a general inclusion of $C^*$-algebras. Then we study an MUO when the inclusion is of index-finite type in the sense of Watatani. We also give an explicit formula for the MUO when the inclusion arises from a crossed product of a $C^*$-algebra by a finite group.